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Literature summary extracted from

  • Canuel, M.; Sun, X.; Asselin, M.C.; Paramithiotis, E.; Prat, A.; Seidah, N.G.
    Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1) (2013), PLoS ONE, 8, e64145.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.61 low density lipoprotein receptor-related protein 1 + H2O Cricetulus griseus degradation ?
-
 ?
3.4.21.61 low density lipoprotein receptor-related protein 1 + H2O Homo sapiens degradation ?
-
 ?
3.4.21.61 low density lipoprotein receptor-related protein 1 + H2O Mus musculus degradation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.61 Cricetulus griseus
-
-
-
3.4.21.61 Homo sapiens
-
-
-
3.4.21.61 Mus musculus Q80W65
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.61 B16-F1 cell
-
 Mus musculus
-
3.4.21.61 B16-F10 cell
-
 Mus musculus
-
3.4.21.61 CHO-13-5-1 cell
-
 Cricetulus griseus
-
3.4.21.61 CHO-A7 cell
-
 Cricetulus griseus
-
3.4.21.61 CHO-K1 cell
-
 Cricetulus griseus
-
3.4.21.61 HEK-293 cell
-
 Homo sapiens
-
3.4.21.61 Hep-G2 cell
-
 Homo sapiens
-
3.4.21.61 liver
-
 Mus musculus
-
3.4.21.61 melanoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.61 low density lipoprotein receptor-related protein 1 + H2O degradation Cricetulus griseus ?
-
 ?
3.4.21.61 low density lipoprotein receptor-related protein 1 + H2O degradation Homo sapiens ?
-
 ?
3.4.21.61 low density lipoprotein receptor-related protein 1 + H2O degradation Mus musculus ?
-
 ?
3.4.21.61 low density lipoprotein receptor-related protein 1 + H2O the enzyme acts on the extracellular domain of the receptor molecule Cricetulus griseus ?
-
 ?
3.4.21.61 low density lipoprotein receptor-related protein 1 + H2O the enzyme acts on the extracellular domain of the receptor molecule Homo sapiens ?
-
 ?
3.4.21.61 low density lipoprotein receptor-related protein 1 + H2O the enzyme acts on the extracellular domain of the receptor molecule Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.61 PCSK9
-
 Cricetulus griseus
3.4.21.61 PCSK9
-
 Homo sapiens
3.4.21.61 PCSK9
-
 Mus musculus
3.4.21.61 proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9
-
 Cricetulus griseus
3.4.21.61 proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9
-
 Homo sapiens
3.4.21.61 proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.21.61 physiological function proprotein convertase subtilisin/kexin 9 enhances the degradation of the LDL receptor in endosomes/lysosomes, resulting in increased circulating LDLc. The enzyme can also mediate the degradation of LDL receptor lacking its cytosolic tail, the transmembrane-domain of the receptor is not involved, but a lysosomal-targeting factor, overview. Role for the enzyme in enhancing tumor metastasis, consequences of enzyme inhibition for lowering LDLc and tumor metastasis Homo sapiens
3.4.21.61 physiological function proprotein convertase subtilisin/kexin 9 enhances the degradation of the LDL receptor in endosomes/lysosomes, resulting in increased circulating LDLc. The enzyme can also mediate the degradation of LDL receptor lacking its cytosolic tail, the transmembrane-domain of the receptor is not involved, but a lysosomal-targeting factor.overview. The LDL receptor is insensitive to the enzyme in murine B16F1 melanoma cells, but the enzyme is able to induce degradation of the low density lipoprotein receptor-related protein 1, suggesting distinct targeting mechanisms for these receptors. Role for the enzyme in enhancing tumor metastasis Mus musculus
3.4.21.61 physiological function proprotein convertase subtilisin/kexin 9 enhances the degradation of the LDL receptor in endosomes/lysosomes, resulting in increased circulating LDLc. The enzyme is capable of acting upon the LDL receptor in CHO 13-5-1 cells lacking LRP-1. It also acts on LRP-1 in the absence of the LDL receptor in CHO-A7 cells, where re-introduction of the LDL receptor leads to reduced enzyme-mediated degradation of LRP-1 Cricetulus griseus